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§15 – A great recipe to be stressed out →

Published July 26, 2018  ·  All posts on Jul 26

This entry is part 27 of 37 in the series Study inspired by Pakour & Art du Déplacement by V. Thibault

Have you noticed: Once you know something, you see it everywhere?

Reading this section, I’m reminded of Joe Erhmann’s ideas from the book “InsideOUT Coaching,” and of Steven Covey’s, “The 7 Habits of Highly Effective People.” Both of which also counsel beginning with what’s inside; Beginning by taking a step back and noticing — perhaps _learning_ to notice is the first step — the broader context.

Over a decade ago, the previous-me was entirely focused inward, on myself, on the small picture. That previous-me molted as I managed to become self aware and began learning empathy. With empathy came the ability to listen and, most recently, the ability to communicate, “How can I help?”

And yet I still regularly find myself stressed out.

My impatience regarding…
fat loss
movement progression
the podcast
memento mori

…grows, and the things I appreciate– the things I have now which I have worked so vary hard for to this point– …well, I’ve grown accustomed to them and while I still internally appreciate them I’ve stopped showing that appreciation externally.

I need to shift my goals.

I need to move the goal posts.

I need to set milestones at smaller intervals.

When you make some new connection, one then suddenly sees it everywhere.

On a recent Saturday — a day I usually jam full of goals — I accidentally set so few goals for the day, that by 4pm I was completely done. Normally, I set my goals at “do all the things” [meme image omitted :], and at some point each day I surrender with a fatalistic, “that’s enough for today!” It took me a long time to get comfortable knowing I’m organized and motivated enough that I will make progress towards my long-term goals. But every day is either a day “off” with rest and relaxation with minimal work towards goals, or a day “on” where everything is ordered– flexible, adjustable, prioritized sure, but ordered none the less.

On this particular Saturday, at 4pm…

It was surreal. It was just a nice feeling, like, “Okay, what do I want to do?” I wandered around in this daze of, “Gee, the weather is nice,” “Wow, the feel of the concrete under my bare feet is nice,” “I’d forgotten to notice how comfortable this chair is,” and “Wow, this food is particularly yummy.”

What was different? Nothing.

I still had — still have! — an enormously-complex, personal productivity system which holds all the things I’m working on. That’s not bad; That’s good. It helps me greatly by remembering everything for me, so I can use my brain for having ideas and doing things. I still have a house with a sort of strange spot on one of the ceilings that I think means the roof might be leaking. I still have a leak in the shower that I haven’t figured out. There’s still some firewood to be split.

…but for one evening — a Saturday from about 4pm until I went to sleep around 9:30 — for one evening, I clearly forgot to put in one (or both!) of the ingredients that make up the recipe for being stressed out.

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Ever-present mental stress →

Published March 7, 2018  ·  All posts on Mar 7  ·  ,

Most people have been in some version of this mental stress state so consistently, for so long, that they don’t even know they’re in it. Like gravity, it’s ever present — so much so that those who experience it usually aren’t even aware of the pressure. The only time most of them will realize how much tension they’ve been under is when they get rid of it and notice how different they feel. It’s like the constant buzzing noise in a room you didn’t know was there until it stops.

~ David Allen from, Getting Things Done

Elsewhere, this is 4uliwo2. — slipbox

The key insight for me was once I realized there are two “directions” to thinking: I was always good at vertical thinking, going down thru a project (big or small), planning, organizing and doing. This was simply “thinking”, and how could there be more than one “direction” in which to think?

Unfortunately, I often got stuck when my brain started doing this other direction of thinking for which I had no name; no concept to attach: The horizontal thinking. The hopping from project to project — and I use “project” in the most broad sense of ANY thing involving a goal (“remodel house”, “send holiday cards”), any size (“seven years of projet management and contractors”, “buy stamps, buy cards, stuff, mail” ), and any number of steps. My mind hopped uncontrollably from thing to thing, around and around, across all the open loops, as the same things came up over and over and over.

These days, having a solid capture and review system enables me to close those mental loops. I can often read for a half an hour without my mind once interrupting me with some random, “I need to do this,” or “I need to remember that,” thought. (And if it does interupt me, I simple capture that thought once. Done. Freedom.) In the beginning I used paper notecards, then notebooks, software, and on and on. The exact system does not matter. It only matters that you trust your system. Only when you truly trust your system will your subconscious close all those open loops.

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The distress of the privileged →

Published January 25, 2015  ·  All posts on Jan 25  ·  

If you are one of the newly-visible others, this all sounds whiny compared to the problems you face every day. It’s tempting to blast through such privileged resistance with anger and insult.

Tempting, but also, I think, a mistake. The privileged are still privileged enough to foment a counter-revolution, if their frustrated sense of entitlement hardens.

So I think it’s worthwhile to spend a minute or two looking at the world from George Parker’s point of view: He’s a good 1950s TV father. He never set out to be the bad guy. He never meant to stifle his wife’s humanity or enforce a dull conformity on his kids. Nobody ever asked him whether the world should be black-and-white; it just was.

~ Doug Muder, from The Distress of the Privileged

Elsewhere, this is 4uwete2. — slipbox

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Time-Restricted Eating as an Adjunct to Radiotherapy and Androgen Deprivation Therapy in Prostate Cancer →

Published April 6  ·  All posts on Apr 6  ·  

Clinical Evidence Brief
Current state of evidence — preclinical, clinical, and investigational
Prepared March 2026

Proposed mechanisms

The biological rationale for combining dietary restriction with radiotherapy centers on the differential stress response.[1] Under conditions of nutrient deprivation, normal cells activate conserved protective pathways — reducing metabolic activity, upregulating stress resistance, and entering a quiescent state. Cancer cells, whose oncogenic mutations constitutively activate RAS, AKT, and mTOR signaling, are largely unable to make this shift; they remain metabolically active and, as a consequence, more vulnerable to radiation-induced damage. Concurrently, normal tissue is relatively protected — a divergence that forms the basis for combining fasting with radiotherapy.

The interaction between dietary restriction and androgen deprivation therapy (ADT) works through different mechanisms that depend on the class of ADT used, as described below. Separately, dietary restriction may also help counteract the metabolic side effects of ADT itself.

Time-restricted eating (TRE) — typically a 16:8 fasting-to-eating window — is among the more clinically feasible implementations of dietary restriction during active treatment, avoiding the weight loss and nutritional risk associated with sustained caloric restriction.[2] Transitioning from typical Western eating patterns to a sustained 16:8 window requires deliberate on-ramping; the author has written separately on a structured approach to this transition.[3]

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Part 5: Inflammation and Immune Renewal →

Published March 4  ·  All posts on Mar 4  ·  

I’ve been doing 16:8 intermittent fasting for years and recently started 48-hour fasts — dropping about three pounds each fast, gaining one or two back, and trending steadily downward. I wanted to understand what the research actually says about what I’m doing to myself, so I worked with Claude (Anthropic’s AI) to produce this series. I set the structure, chose the topics, pushed back on claims that felt hand-wavy, and guided the editorial tone. Claude did the writing and research synthesis. My curiosity driving Claude’s research and prose.

Inflammation and Immune Renewal

Research brief — how fasting reduces systemic inflammation and primes the immune system for regeneration. Two distinct but related mechanisms.

Inflammation Reduction

Jordan et al. 2019 — Stefan Jordan, Navpreet Tung, and colleagues at the Icahn School of Medicine at Mount Sinai, led by Miriam Merad. Published in Cell, 178:1102-1114. (1)

This study directly tied caloric intake to the circulating inflammatory monocyte pool — a key driver of systemic inflammation.

What they found:

  • Short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes
  • The mechanism: fasting activates AMPK in hepatocytes (liver cells) and suppresses systemic CCL2 production via PPARα, which reduces monocyte mobilization from bone marrow
  • Fasting improved chronic inflammatory diseases without compromising emergency immune mobilization during acute infection — the immune system’s ability to respond to real threats remained intact
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Part 3: Cellular Cleanup →

Published March 4  ·  All posts on Mar 4  ·  

I’ve been doing 16:8 intermittent fasting for years and recently started 48-hour fasts — dropping about three pounds each fast, gaining one or two back, and trending steadily downward. I wanted to understand what the research actually says about what I’m doing to myself, so I worked with Claude (Anthropic’s AI) to produce this series. I set the structure, chose the topics, pushed back on claims that felt hand-wavy, and guided the editorial tone. Claude did the writing and research synthesis. My curiosity driving Claude’s research and prose.

Autophagy

Research brief — what autophagy is, what the evidence actually shows, and where the common claims outrun the science.

What Autophagy Is

Autophagy — from Greek auto (“self”) and phagein (“to eat”) — is the process by which cells degrade and recycle damaged organelles, misfolded proteins, and dysfunctional mitochondria. Think of it as cellular housekeeping: damaged parts get broken down and the raw materials get repurposed for repair and new construction.

Yoshinori Ohsumi won the 2016 Nobel Prize in Physiology or Medicine for discovering the genetic mechanisms of autophagy. Working in baker’s yeast in the early 1990s, he identified the genes essential for the process. The mechanisms are highly conserved across species including humans. (1)

The molecular trigger is well-understood: nutrient deprivation suppresses insulin and mTOR signaling and activates AMPK — all of which are upstream regulators of autophagy. The logical chain from “fasting → reduced insulin/mTOR → autophagy activation” is mechanistically solid. Disrupted autophagy has been linked to Parkinson’s disease, type 2 diabetes, Alzheimer’s, certain cancers, and many infections. (2)

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Part 2: Getting Into Fasting →

Published March 4  ·  All posts on Mar 4  ·  

I’ve been doing 16:8 intermittent fasting for years and recently started 48-hour fasts — dropping about three pounds each fast, gaining one or two back, and trending steadily downward. I wanted to understand what the research actually says about what I’m doing to myself, so I worked with Claude (Anthropic’s AI) to produce this series. I set the structure, chose the topics, pushed back on claims that felt hand-wavy, and guided the editorial tone. Claude did the writing and research synthesis. My curiosity driving Claude’s research and prose.

Routines, Scenarios, and What to Expect

Research brief — the practical onramp. 16:8 IF as a starting point, Craig’s specific eating window, extended fasting scenarios anchored to a weekly rhythm, and what keto flu actually is.

Start With 16:8

You may want to start by getting into 16:8 intermittent fasting — an 8-hour eating window and 16-hour fast — before attempting anything longer.

Is this actually supported? Honestly, no one has studied whether practicing 16:8 first makes longer fasts easier. It’s conventional wisdom without a clinical trial behind it. But the physiological rationale is sound: regular time-restricted eating develops metabolic flexibility — the ability to switch between glucose and fat/ketone oxidation. Someone who does this daily would be expected to enter ketosis faster and with less discomfort during an extended fast. And the practical experience of managing hunger, learning your body’s signals, and knowing what electrolyte depletion feels like are real benefits of prior fasting experience, even if unstudied. (1)

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Part 1: Why Fasting Works →

Published March 4  ·  All posts on Mar 4  ·  

I’ve been doing 16:8 intermittent fasting for years and recently started 48-hour fasts — dropping about three pounds each fast, gaining one or two back, and trending steadily downward. I wanted to understand what the research actually says about what I’m doing to myself, so I worked with Claude (Anthropic’s AI) to produce this series. I set the structure, chose the topics, pushed back on claims that felt hand-wavy, and guided the editorial tone. Claude did the writing and research synthesis. My curiosity driving Claude’s research and prose.

The Big Picture

Research brief — general overview of fasting benefits. The most “hand-wavy” of the series: frameworks, history, and the broad case for why not eating is doing something useful.

The Metabolic Switch

The overarching framework for understanding fasting benefits comes from Mark Mattson’s “metabolic switch” concept, reviewed comprehensively in a landmark 2019 NEJM paper co-authored with Rafael de Cabo. (1)

The core idea: when you stop eating for long enough, the body shifts from glucose-based to ketone-based energy. This isn’t just a fuel swap — it’s a stress response that activates adaptive cellular pathways. The metabolic stress of fasting triggers increased expression of antioxidant defenses, DNA repair, protein quality control, mitochondrial biogenesis, and autophagy. These protective mechanisms outlast the fast itself — a hormetic effect where controlled stress leaves the system stronger.

This is the thread that connects the individual benefits explored in the rest of this series: better insulin sensitivity, growth hormone surges, inflammation reduction, cellular cleanup, and (possibly) neurological benefits all flow from this same metabolic switch.

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Remodeling with Sean Hannah →

Published February 2  ·  All posts on Feb 2  ·  

Remodeling with Sean Hannah

What does it take to stop avoiding pain and instead use it as a guide for rebuilding the body?

The same movements that caused injury can heal it when performed slowly, partially, and with intention.

What we try to do is get people to understand that if you have pain, if you have a limitation, you don’t stop doing the thing that hurt it. You do the thing that hurt it, slow, partial, light, take it down to the baby amount, the tolerable amount, and then start pushing it back up the scale. And by the time you can do it fast and heavy again, you’re healed. Congratulations.

~ Sean Hannah (9:19)

The conversation explores why most people avoid the slow, deliberate work required to truly rehabilitate injuries rather than just return to basic function. The distinction between physical therapy (designed for baseline recovery) and full joint remodeling (a months-to-years process typically reserved for elite athletes) forms the foundation of the discussion. The key insight is that healing requires doing the same movements that caused injury—but slower, lighter, and more partial—rather than avoiding them entirely.

Pain emerges as a multifaceted phenomenon with three distinct layers: actual tissue damage, neuropathic pain (trauma responses encoded in nerves and fascia), and centralized pain (psychological amplification based on beliefs and language). The conversation addresses how someone might present with a knee problem but actually need a full head-to-toe biomechanical remodel, with the knee simply being where the dysfunction surfaces most visibly. The discussion also touches on the origins of the nickname “Seanobi” (an Irish ninja wordplay), the value of intuitive three-dimensional movement versus linear athletic training, and the importance of having something worth playing for as the motivational spark that makes the difficult rehabilitation process possible.

(more…)

It’s the messiness →

Published July 11, 2025  ·  All posts on Jul 11  ·  

It turned out in retrospect that the messy diversity of the forest had been the source of its resilience. When stresses such as storms, disease, drought, fragile soil, or severe cold struck, a diverse forest with its full array of different species of trees, birds, insects, and animals was far better able to survive and recover. A windstorm that toppled large, old trees would typically spare smaller ones. An insect attack that threatened oaks might leave lindens and hornbeams unaffected. The rigidity and uniformity of the system meant that failures were not small and contained but systemic.

~ Tiago Forte, from Productive Disorder: The Hidden Power of Chaos, Noise, and Randomness

Elsewhere, this is 4ufobo11. — slipbox

I’m simply stuck, staring at: “The rigidity […] of the system meant that failures were […] systemic.” I’m filing this under Stuff I Wished I’d Learned 30 Years Ago. I often say that I use systems and structure as a way to multiply my efforts. And that’s true. But I’ve learned that the real reason is that I’m afraid. The big why behind my hyper-organization, maximally-complex systems, and endless aligning of figurative ducks is my desperately trying to control the world around me. With realization comes… the recognition that I have a lot more work to learn to not do.

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