Metabolic advantage

(Part 11 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/ketones-and-ketosis/karl-popper-metabolic-advantage-and-the-c57bl6-mouse/

Instead of looking at the equation as one that can be driven only from the right side, let’s look at it from the position that it may be driven from the left. What if the change in weight drove the amount of calories eaten and the amount of caloric energy dissipated? I can think of one situation where the equation makes perfect sense looked at that way.

~ Michael Eades

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Inflammation and intermittent fasting

(Part 12 of 25 in series, M. Eades' Blog)

These posts, particularly the one on inflammation, inspired a host of questions on whether intermittent fasting decreases inflammation. Based on my knowledge of the medical literature on inflammation and intermittent fasting I’m pretty sure that it does. A recent paper presents data indicating that it indeed does.

The April 2007 issue of Annals of Nutrition and Metabolism includes an article on the positive changes in inflammatory markers brought about by the intermittent fasting Muslims undergo during Ramadan.

~ Michael Eades from, http://www.proteinpower.com/drmike/intermittent-fasting/inflammation-and-intermittent-fasting/

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Metabolism and ketosis

(Part 13 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/ketones-and-ketosis/metabolism-and-ketosis/

If you read any medical school biochemistry textbook, you’ll find a section devoted to what happens metabolically during starvation. If you read these sections with a knowing eye, you’ll realize that everything discussed as happening during starvation happens during carbohydrate restriction as well. There have been a few papers published recently showing the same thing: the metabolism of carb restriction = the metabolism of starvation. I would maintain, however, based on my study of the Paleolithic diet, that starvation and carb restriction are simply the polar ends of a continuum, and that carb restriction was the norm for most of our existence as upright walking beings on this planet, making the metabolism of what biochemistry textbook authors call starvation the ‘normal’ metabolism.

~ Michael Eades

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Copper and low carb diets

(Part 14 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/uncategorized/low-carb-diets-and-copper/

Zinc and copper are absorbed through the same ionic channel, and when there is an overabundance of zinc it gets absorbed instead of the copper. […] Certain elements in their ionic form get absorbed through the same channel. As long as these elements present to the channel in a specific ratio, they get through in that same ratio. If, however, there is an overabundance of one, it occupies the channel, preventing the other from getting through and can create an deficiency of the other despite an adequate intake.

~ Michael Eades

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Low-carb adaptation

(Part 15 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/ketones-and-ketosis/lt-frederick-schwatka-and-low-carb-adaptation/

There is an adaptation period that takes place when starting a low-carb diet. Someone who has been on a high-carb diet–the standard American diet, for example–has to metabolize a lot of sugar. All metabolic processes require enzymes to carry them out. Our DNA codes for these enzymes, but we don’t make them unless we need them. And when we do need them it takes a while for them to get brought up to the necessary levels. So, when we’re on a high-carb diet, we’ve got a lot of sugar-metabolizing enzymes kicking around, ready to metabolize sugar. All the sugar-metabolizing pathways are working efficiently.

~ Michael Eades

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Longevity and membrane saturation

(Part 16 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/uncategorized/longevity-and-membrane-saturation/

The cell membranes of both young and old honey bee queens are highly monounsaturated with very low content of polyunsaturates. Newly emerged workers have a similar membrane fatty acid composition to queens but within the first week of hive life, they increase the polyunsaturate content and decrease the monounsaturate content of their membranes, probably as a result of pollen consumption. This means their membranes likely become more susceptible to lipid peroxidation in this first week of hive life. The results support the suggestion that membrane composition might be an important factor in the determination of maximum life span.

~ Michael Eades

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Persistent organic pollutants

(Part 17 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/weight-loss/a-legitimate-use-for-orlistat/

Organochlorine pesticides (DDT, lindane, etc), organochlorine and organobromine industrial pollutants, solvents, placticizers, and a host of other such substances are in the stored fat of all of us. Their use over the previous decades has so filled our environment with these chemicals that we can’t escape them. The are in the air, they fall in the rain, they are in the groundwater. Consequently, they are in our food. Whenever we eat, we get a load of these persistent organic pollutants (POPs) that make their way into our fat cells and cells in other tissues. And they build up because we can’t get rid of them.

~ Michael Eades

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Dietary protein increases lean mass

(Part 19 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/weight-loss/dietary-protein-increases-lean-mass/

I know that many female readers will not want to gain extra muscle.  They shouldn’t worry, however, because in the absence of exogenous anabolic steroids women won’t become ‘muscle bound’ or non-feminine appearing.  What generally happens is that the muscle replaces fat within the muscle.  We’ve all seen marbling in beef, which is fat within the muscle tissue.  With the extra protein, new muscle replaces this fat, and the muscle may even become a little smaller in females while at the same time becoming more dense and stronger.

~ Michael Eades

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Agriculturalists and hunter-gathers

(Part 20 of 25 in series, M. Eades' Blog)

http://www.proteinpower.com/drmike/low-carb-diets/nutrition-and-health-in-agriculturalists-and-hunter-gatherers/

The anthropological record of early man clearly shows health took a nosedive when populations made the switch from hunting and gathering to agriculture. It takes a physical anthropologist about two seconds to look at a skeleton unearthed from an archeological site to tell if the owner of that skeleton was a hunter-gatherer or an agriculturist.

~ Michael Eades

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