Cancer

Why did I start this?

November 4

Your intellectual appetites might include knowing the answer to a mathematics problem; the satisfaction of receiving a text from someone you have a crush on; or getting a coveted job offer. These things won’t necessarily cause physical pleasure. They might spill over into physical enjoyment, but they are not dependent on it. Rather, the pleasure is primarily intellectual.

[…] But, for most people, such joy is fleeting. There is always something else to strive for – and this keeps most of us in a constant, sometimes painful, state of never-satisfied striving. And that striving for something that we do not yet possess is called desire. Desire doesn’t bring us joy because it is, by definition, always for something we feel we lack. Understanding the mechanism by which desires take shape, though, can help us avoid living our lives in an endless merry-go-round of desire.

~ Luke Burgis, from How to know what you really want

I have cancer.

Although I won’t be sharing specifics, I have stellar care and support, from my family, and from a huge team of the best healthcare professionals. My prognosis is excellent. If one must get cancer, you want to have the experience I’m having.

You may have noticed that I’ve not published a podcast episode since something like May. That’s when I started working through my diagnosis, and that’s when I intentionally pressed the pause-button on some of my current projects. I’ve been a guest on a couple of podcasts this year, and that has kept alive a warm ember of my passion for this wonderful art-form.

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Warburg’s finding

July 24, 2019

In 1924 a scientist named Otto Warburg happened upon a counterintuitive finding. Cancer cells, even in the presence of sufficient oxygen, underwent a type of metabolism cells reserved for rapid energy demand – anaerobic metabolism. In fact, even when cancer cells were given additional oxygen, they still almost uniformly defaulted into using only glucose to make ATP via the anaerobic pathway. This is counterintuitive because this way of making ATP is typically a last resort for cells, not a default, due to the very poor yield of ATP.

~ Peter Attia from, https://peterattiamd.com/way-exploit-metabolic-quirk-cancer/

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This is a simple introduction to the two methods our cells can use to get the energy they need to do everything; One way is efficient and one is not. It’s critical that our cells can switch between the two methods as circumstances change. The curious discovery made by Warburg is that cancer cells always use the inefficient method.

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